Toltrazuril (Compare to the active ingredients of 35%) is the result of research efforts to help treat EPM. Thanks to its characteristics, it represents a new standard in coccidiosis control in Race Horses, Camels, Pigeons, Greyhounds & Alpacas.
Toltrazuril (Compare to the active ingredients of 35%) belongs to the chemical group of symmetric triazinons and is not chemically related to any other anticoccidial drug currently used in veterinary medicine. This is a 35% solution.
Due to its particular mode of action, which affects all intracellular structures of Coccidia, Toltrazuril (Compare the active ingredient of 5%) demonstrates very high efficacy, as shown by the following benefits:
– prevents or reduces the severity of lesions,
– stops oocyst shedding,
– improves growth rate,
– improves feed conversion.
These product characteristics make 35% suitable for both therapy and metaphylaxis in domesticated animals.
Toltrazuril represents a very important tool in the control of coccidia problems.
Toltrazuril damages all intracellular development stages of Eimeria (= Coccidia).
Toltrazuril affects schizonts, micro- and macrogametes, but not the tissue cells of the host animals, as was shown in light and electron microscopic studies. These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which is responsible for the respiratory metabolism of Coccidia. In the magrometes, toltrazuril damages the so-called wall-forming bodies. In all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum. Toltrazuril thus has a coccidiocidal mode of action. The special mode of action results in the following advantages:
– toltrazuril acts on all intracellular developmental stages,
– toltrazuril does not interfere with the development of immunity,
– follow-up treatment usually is not necessary,
– even an advanced infection (after 3 5 days; gametogony) can still be treated successfully,
– the efficacy of toltrazuril is independent of the severity of the infection.